PKRRATING THINGS TO KNOW BEFORE YOU BUY

The activated enzyme then phosphorylates its major substrate, the translational initiation variable eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to unique stimuli12, triggering the built-in st